Play a normal Risk of Rain 2 run as any survivor, with Vampire Survivors and The Binding of Isaac mixed in.
Earn Vampire Survivors weapons.
You spawn as the plain RoR2 survivor. Every kill drops a VS XP gem.
Each level-up pauses the game and offers three cards: a new auto-firing weapon (Whip, Magic Wand, Knife, Axe, Cross, King Bible, Fire Wand, Garlic, Santa Water) or an upgrade up to level 8.
You can hold up to 6 weapons. They hit as your survivor, so your RoR2 on-hit items proc from them.
The monster director spawns much bigger waves of monsters.
Binding of Isaac items.
Every stage starts with an Isaac item pedestal ahead of you.
Beat the teleporter for another pedestal and a Devil deal: Brimstone's blood laser, Abaddon, Pentagram, The Mark, The Pact, Ceremonial Robes or Whore of Babylon, each paid for with max HP.
Isaac items change your survivor's own attacks as well as the VS weapons:
Inner Eye: extra bullets and projectiles.
Polyphemus and friends: bigger explosions (skills, projectiles, item procs like Gasoline), thicker bullets, bigger melee hitboxes and effects.
Mom's Knife: piercing bullets.
Spoon Bender: homing shots.
Damage, speed, HP and cooldowns change too.
The real things, from your own games.
Weapon icons, gems, sounds and music are read live from your Vampire Survivors install. VS music replaces RoR2's, with boss music while the teleporter charges.
Isaac's item sprites, pedestals and sounds come from your Isaac install.
Nothing from either game is shipped.
On the first launch, Isaac's own ResourceExtractor (it comes with Isaac) unpacks its art into your Isaac folder's extracted_resources. That takes about 3 minutes, and Isaac itself is unchanged.
Single player. Needs Risk of Rain 2, Vampire Survivors and The Binding of Isaac: Rebirth.