Isaac's bosses invade Undertale: fight or spare Monstro, the Duke of Flies, Gurdy and Mom as Isaac's tear-firing SOUL.
Undertale x The Binding of Isaac: Rebirth. You play Undertale as Frisk, and Isaac's basement comes up into the Underground.
In every battle the red heart is Isaac's head. Hold Z during the enemy's turn and he fires tears up at the monsters. They pop Isaac bosses' shots and chip at any monster's HP, but the last blow is still yours to choose: FIGHT or MERCY.
The first random encounter in each area is that area's Isaac boss, in a real Undertale battle with Isaac's own sprites, sounds and boss music:
Spare them or beat them. Either way they drop an Isaac item.
The Sad Onion, Spoon Bender, Cricket's Head, Lunch, The Inner Eye, Polyphemus, Brimstone and The Halo work as Undertale items. Use one to swallow it and upgrade Isaac's tears for the rest of your run: tears up, homing, damage up, max HP, triple shot, mega tears, a charged blood laser, all stats up. Every shop sells one too: Snowdin, Tem Shop, Gerson, Bratty and Catty, and MTT Resort.
Credits: Undertale by Toby Fox. The Binding of Isaac: Rebirth by Edmund McMillen and Nicalis. Uses xdelta3 (GPL-2.0, source included). Patch built with UndertaleModTool.